PIs: Abigail Powers Lott, PhD, ABPP & Briana Woods-Jaeger, PhD
The cumulative effects of adverse childhood experiences (ACEs), including trauma exposure, parent mental health problems, family dysfunction, and experiences of racism can lead to prolonged activation of stress response systems, known as toxic stress. Toxic stress is increasingly recognized as an important contributor to socioeconomic and racial health disparities that emerge in early childhood and may persist across generations.
African American women experience significant disparities in maternal and infant mortality, some of which may be attributable to toxic stress. The toxic stress response may increase risk factors for maternal and infant morbidity and mortality such as high-levels of stress hormones, high blood pressure, maternal PTSD and depression. Further, heightened maternal stress responses in pregnancy are associated with heightened infant stress responses, increasing the risk for the intergenerational transmission of toxic stress.
Developing and implementing prenatal interventions that address critical factors related to health disparities such as toxic stress and associated co-morbidities is warranted. Mindfulness-based interventions have demonstrated efficacy for a variety of mental health conditions, including depression and PTSD, are cost-effective, and scalable in diverse settings.
This study will utilize a randomized controlled trial (RCT) design along with a multi method psychological and physiological assessment approach to establish the feasibility and acceptability of an 8-session Dialectical Behavior Therapy (DBT) skills group versus wait-list control in pregnant African American women with PTSD or depression symptoms. Implementing mindfulness interventions for African American pregnant women with histories of ACEs and current depression and/or PTSD symptoms is novel and has the potential to interrupt the intergenerational cycle of toxic stress by improving maternal stress response and mental health.