Intergenerational and Developmental Projects

There are many components to the Grady Trauma Project. Patients enrolled in the Grady Trauma Project may be eligible for a number of other areas of research. One of those involves the study of intergenerational transmission of trauma.

 

Mechanisms of Intergenerational Impact of Maternal Trauma (NICHD R01)

PI: Bekh Bradley

This study examines biological, psychological, and physiological measures of offspring variables for children from mothers with high levels of civilian trauma. This is a longitudinal study that will follow mothers and their school-age children for four years; maternal PTSD and trauma, as well as parenting behavior and genetics, will be used to predict child outcomes. The goal is to understand the multi-variate mechanisms contributing to increased risk for PTSD in children of highly traumatized mothers.

Development, Trauma, and Genotype Effects on Biomarkers of Anxiety in Children (NIMH R01)

PI: Tanja Jovanovic

This project will prospectively examine effects of genotype, age, and puberty on fear-potentiated startle and dark-enhanced startle in children and adolescents from a high-risk population. Specifically, the aims of the grant will investigate the role of PAC1R gene polymorphisms, trauma exposure, and estrogen and testosterone changes on the development of fear-related physiological responses.

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Fear-Potentiated Startle as a Biomarker of Anxiety in Children of Mothers with PTSD (NARSAD)

PI: Tanja Jovanovic

This project examines endophenotypes of anxiety in children of mothers with and without PTSD. This study investigates the precursors of stress-related psychopathology in children by assessing biologically based risk factors in physiological paradigms developed from basic neuroscience animal models to test children of mothers with and without PTSD, in order to describe biomarkers of anxiety in children of trauma-exposed women.

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