When you experience a trauma, it can impact your emotions, your body, and how you experience yourself and others. Trauma can include many things, but generally includes exposure to events that are unusually or especially frightening or horrible, such as witnessing death or experiencing serious injury or sexual violence. Experiencing many different traumas throughout your life can increase your risk for many negative health outcomes, including posttraumatic stress disorder (PTSD). Cumulative trauma exposure is associated with increased risk of PTSD and women are twice as likely as men to develop PTSD. Importantly, PTSD risk is intergenerational; children of mothers with PTS are more likely to have PTSD themselves. Despite intergenerational risk associated with PTSD, there remains little known about the impact of maternal PTSD on infant biological risk outcomes or clear pathways of risk and resilience that can be translated into treatment targets.